Fbxo2 antibody - C-terminal re

商品分类：多克隆抗体

来源：Rabbit

存储溶液：Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

特异性：Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Guinea Pig, Dog

别名：F-box only protein 2, Fbxo2, Fbs1, Fbx2

简单描述：Rabbit Polyclonal Fbxo2 antibody - C-terminal region. Validated for use in WB.

详情：Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. Cellular_Location Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side Tissue_Location Detected in brain and cochlea, in epithelial support cells and hair cells of the organ of Corti (at protein level).