产品概述:Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
来源:Rabbit
参考文献:Dear T.N.,et al.Genomics 45:175-184(1997).Crotty P.L.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.Belsito A.,et al.Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.Ross M.T.,et al.Nature 434:325-337(2005).Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
简单描述:Rabbit Polyclonal CAPN6 / Calpain 6 Antibody (C-Terminus). Validated for use in WB, IHC-P, IF.
详情:FunctionMicrotubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).Cellular_LocationCytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindleTissue_LocationExpressed only in placenta.