靶点/蛋白:ABD11405 recognises tissue factor pathway inhibitor (TFPI), also known as Lipoprotein-associated coagulation inhibitor (LACI). TFPI is a protease inhibitor that helps to maintain haemostasis by inhibiting factor Xa and the Factor VIIa/Tissue factor (TF) complex. TFPI is also reported to associate with lipoproteins in plasma.
来源:Goat
参考文献:1. Wun, T. C. et al. (1988) Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.J. Biol. Chem. 263: 6001 - 6004.