Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名:
MCF2 Antibody (C-term)
供应商:
安诺伦(北京)生物科技有限公司
商品分类:多克隆抗体
产品概述:The oncogenic protein encoded by this gene is a guaninenucleotide exchange factor (GEF) that exerts control over somemembers of the Rho family of small GTPases. Several transcriptvariants encoding different isoforms have been found for this gene.These isoforms exhibit different expression patterns and varyinglevels of GEF activity.
靶点/蛋白:This MCF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 804-833 amino acids from the C-terminal region of human MCF2.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Piton, A., et al. Mol. Psychiatry (2010) In press :Murakami, M., et al. Int. J. Cancer 123(3):500-510(2008)Murakami, M., et al. Cancer Biol. Ther. 7(5):677-688(2008)Rojas, R.J., et al. J. Biol. Chem. 282(40):29201-29210(2007)Prag, S., et al. Mol. Biol. Cell 18(8):2935-2948(2007)
简单描述:Rabbit Polyclonal MCF2 Antibody (C-term). Validated for use in WB, IHC-P, FC, E.
详情:FunctionGuanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.Cellular_LocationCytoplasm. Isoform 3: Membrane. Note=Colocalizes with CDC42 to plasma membraneTissue_LocationIsoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis