Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名:
SRA1 Antibody (C-term)
供应商:
安诺伦(北京)生物科技有限公司
商品分类:多克隆抗体
产品概述:This gene is involved in transcriptional coactivation bysteroid receptors. There is currently data suggesting this geneencodes both a non-coding RNA that functions as part of aribonucleoprotein complex and a protein coding mRNA. Increasedexpression of both the transcript and the protein is associatedwith cancer.
靶点/蛋白:This SRA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-222 amino acids from the C-terminal region of human SRA1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Yao, H., et al. Genes Dev. 24(22):2543-2555(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Beauvillain, C., et al. J. Hepatol. 52(5):644-651(2010)Foulds, C.E., et al. Mol. Endocrinol. 24(5):1090-1105(2010)Chooniedass-Kothari, S., et al. FEBS Lett. 584(6):1174-1180(2010)
简单描述:Rabbit Polyclonal SRA1 Antibody (C-term). Validated for use in WB, E.
详情:FunctionFunctional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.Cellular_LocationNucleus. CytoplasmTissue_LocationHighly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus