Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名:
PBK Antibody (C-term C300)
供应商:
安诺伦(北京)生物科技有限公司
规格:
400 μl
商品分类:多克隆抗体
产品概述:PBK is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
靶点/蛋白:This PBK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-317 amino acids from the C-terminal region of human PBK.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Nandi, A., et al., Blood Cells Mol. Dis. 32(1):240-245 (2004).Simons-Evelyn, M., et al., Blood Cells Mol. Dis. 27(5):825-829 (2001).Zhao, S., et al., Int. J. Biochem. Cell Biol. 33(6):631-636 (2001).Abe, Y., et al., J. Biol. Chem. 275(28):21525-21531 (2000).Gaudet, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(10):5167-5172 (2000).
特异性:Human
别名:Lymphokine-activated killer T-cell-originated protein kinase, Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase, PBK, TOPK
应用:WB~~1:1000IHC-P~~1:10~50
简单描述:Rabbit Polyclonal PBK Antibody (C-term C300). Validated for use in WB, IHC-P, E.
详情:FunctionPhosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.Tissue_LocationExpressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.