Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名:
NR4A1 / NUR77 Antibody (N-Terminus)
供应商:
安诺伦(北京)生物科技有限公司
规格:
50 μg
商品分类:多克隆抗体
产品概述:Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
靶点/蛋白:Human NUR77. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
来源:Rabbit
参考文献:Nakai A.,et al.Mol. Endocrinol. 4:1438-1443(1990).Chang C.,et al.J. Steroid Biochem. 34:391-395(1989).Ohkura N.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.Kobayashi T.,et al.Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.Kaighin V.A.,et al.Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
特异性:Human, Mouse, Hamster
别名:Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1
应用:IHC-P (16 μg/ml)
简单描述:Rabbit Polyclonal NR4A1 / NUR77 Antibody (N-Terminus). Validated for use in IHC-P.
详情:FunctionOrphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.Cellular_LocationCytoplasm. Nucleus.Tissue_LocationFetal muscle and adult liver, brain and thyroid