Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名:
NALP3 / NLRP3 Antibody (N-Terminus)
供应商:
安诺伦(北京)生物科技有限公司
规格:
50 μg
商品分类:多克隆抗体
产品概述:May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
靶点/蛋白:Human NLRP3. Immunogenic peptide shares 75% homology with the mouse sequence. The antibody has not been specifically tested with mouse samples at this time. Cross-reactivity or lack thereof therefore cannot be guaranteed.
别名:NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
应用:IHC-P (2.5 μg/ml), WB (1-2 μg/ml),
简单描述:Rabbit Polyclonal NALP3 / NLRP3 Antibody (N-Terminus). Validated for use in WB, IHC-P, IF, E.
详情:FunctionMay function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.Cellular_LocationCytoplasmTissue_LocationExpressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder