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- 2025年07月11日
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- 详细信息
- 技术资料
- 保存条件：
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 英文名：
Histone Methyltransferase (SUV39H1) Antibody
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
100 μg
商品分类：多克隆抗体
产品概述：The histone methyltransferase KMT1A / SUV39H1 is the mammalian homologue of the Drosophila PEV modifier Su(var)3-9 protein. SUV39H1 contains the SET and chromo domains. In eukaryotic cells, SUV39H1 and the methyl-lysine binding protein HP1 interact to repress transcription at heterochromatic sites. SUV39H1 methylates histone H3 on lysine 9, which generates a binding site for HP1 proteins that plays a role in heterochromatin formation and gene silencing.
靶点/蛋白：HMT (SUV39H1)
来源：Rabbit
特异性：Human, Mouse, Rat, Drosophila
别名：Histone-lysine N-methyltransferase, SUV39H1, Histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, Full=Position-effect variegation 3-9 homolog, Suppressor of variegation 3-9 homolog 1, Su(var)3-9 homolog 1
简单描述：Rabbit Polyclonal Histone Methyltransferase (SUV39H1) Antibody. Validated for use in WB.
详情：Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1- stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. Cellular_Location Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere Note=Associates with centromeric constitutive heterochromatin Tissue_Location Widely expressed.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
产品概述：The histone methyltransferase KMT1A / SUV39H1 is the mammalian homologue of the Drosophila PEV modifier Su(var)3-9 protein. SUV39H1 contains the SET and chromo domains. In eukaryotic cells, SUV39H1 and the methyl-lysine binding protein HP1 interact to repress transcription at heterochromatic sites. SUV39H1 methylates histone H3 on lysine 9, which generates a binding site for HP1 proteins that plays a role in heterochromatin formation and gene silencing.
靶点/蛋白：HMT (SUV39H1)
来源：Rabbit
特异性：Human, Mouse, Rat, Drosophila
别名：Histone-lysine N-methyltransferase, SUV39H1, Histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, Full=Position-effect variegation 3-9 homolog, Suppressor of variegation 3-9 homolog 1, Su(var)3-9 homolog 1
简单描述：Rabbit Polyclonal Histone Methyltransferase (SUV39H1) Antibody. Validated for use in WB.
详情：Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1- stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. Cellular_Location Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere Note=Associates with centromeric constitutive heterochromatin Tissue_Location Widely expressed.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
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Histone Methyltransferase (SUV39H1) Antibody | LBP61726 | Leading Biology
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