Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名:
CD105/Endoglin Antibody (Center E395)
供应商:
安诺伦(北京)生物科技有限公司
规格:
100 μl
商品分类:多克隆抗体
产品概述:Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
靶点/蛋白:CD105
来源:Rabbit
特异性:Human
别名:ENG; END; Endoglin
简单描述:Rabbit Polyclonal CD105/Endoglin Antibody (Center E395). Validated for use in WB, IHC, FC.
详情:FunctionMajor glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.Cellular_LocationMembrane; Single-pass type I membrane proteinTissue_LocationEndoglin is restricted to endothelial cells in all tissues except bone marrow