产品概述:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
靶点/蛋白:KLRC3 (NP_002252, 132 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
来源:mouse
存储溶液:Clear, colorless solution in phosphate buffered saline, pH 7.2.
参考文献:1.Glycosylation-related gene expression is linked to differentiation status in glioblastomas undifferentiated cells.Cheray M, Petit D, Forestier L, Karayan-Tapon L, Maftah A, Jauberteau MO, Battu S, Gallet FP, Lalloue F.Cancer Letters (2011), doi: 10.1016/ j.canlet.2011.07.027
特异性:Human
别名:NKG2-E type II integral membrane protein, NK cell receptor E, NKG2-E-activating NK receptor, KLRC3, NKG2E
应用:WB~~1:500~1000
简单描述:mouse Monoclonal KLRC3 Antibody (monoclonal) (M01). Validated for use in WB, E. Clone: 3D5.