靶点/蛋白:Mouse anti-Human CD89 antibody, clone MIP8a recognizes the human CD89 cell surface antigen, a 50-75kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R).CD89 is expressed by peripheral blood monocytes and neutrophils.MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes.
来源:Mouse
参考文献:1. Zhang, W. et al. (2000) Neutrophil lactoferrin release induced by IgA immune complexes differed from that induced by cross-linking of fcalpha receptors (FcalphaR) with a monoclonal antibody, MIP8a.Clin Exp Immunol. 121 (1): 106-11. 2. Lu, J. et al. (2011) Recognition and functional activation of the human IgA receptor (Fc{alpha}RI) by C-reactive protein. Proc Natl Acad Sci U S A. 108: 4974-9. 3. Duc, M. et al. (2010) Antigen binding to secretory immunoglobulin A results in decreased sensitivity to intestinal proteases and increased binding to cellular Fc receptors.J Biol Chem. 285: 953-60. 4. Wu, J. et al. (2007) FcαRI (CD89) alleles determine the proinflammatory potential of serum IgA.J Immunol. 178: 3973-82. 5. Hamre, R. et al. (2003) Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissue.Scand J Immunol. 57: 506-16. 6. Qian,K. et al. (2008) Functional expression of IgA receptor FcalphaRI on human platelets.J Leukoc Biol. 84: 1492-500. 7. Van Egmond, M. (2011) Method for the treatment or prophylaxis of chronic inflammatory diseases.European Patent Application No: 12/736963 8. Pascal, V. et al. (2012) Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells.Haematologica. 97 (11): 1686-94. 9. Mladenov, R. et al. (2015) The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia.Int J Cancer. 137 (11): 2729-38.
特异性:Human
别名:Immunoglobulin alpha Fc receptor, IgA Fc receptor, CD89, FCAR, CD89
简单描述:Mouse Monoclonal Anti-Human CD89 Antibody, clone MIP8a (RPE). Validated for use in WB, FC, E, IP. Clone: MIP8a.