产品概述:The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
靶点/蛋白:SMAD7 (NP_005895, 160 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
来源:Mouse
存储溶液:Clear, colorless solution in phosphate buffered saline, pH 7.2.
参考文献:1.Aberrant expression in multiple components of the transforming growth factor-?]1-induced Smad signaling pathway during 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell carcinogenesis.Chen YK, Yang SH, Huang AH, Hsue SS, Lin LM.Oral Oncol. 2011 Feb 26. [Epub ahead of print]
特异性:Human
别名:Mothers against decapentaplegic homolog 7, MAD homolog 7, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, MAD homolog 8, Mothers against DPP homolog 8, SMAD family member 7, SMAD 7, Smad7, hSMAD7, SMAD7, MADH7, MADH8
应用:WB~~1:500~1000
简单描述:Mouse Monoclonal SMAD7 Antibody (monoclonal) (M09). Validated for use in WB, IHC, E. Clone: 1G10.