产品概述:The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. ; ; ; ; ;
来源:Mouse
参考文献:1. Cancer Immunol Immunother. 2012 Sep;61(9):1359-71. 2. Lupus. 2012 Sep;21(10):1098-104.
特异性:Human
别名:Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M
简单描述:Mouse Monoclonal B2M Antibody. Validated for use in WB, IHC, FC, ICC, E. Clone: 4G5A1.
详情:FunctionComponent of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.Cellular_LocationSecreted. Note=Detected in serum and urine