产品概述:This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene.
靶点/蛋白:ZIC4 (NP_115529, 249 a.a. ~ 319 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
来源:mouse
存储溶液:Clear, colorless solution in phosphate buffered saline, pH 7.2.
参考文献:[Technology of analysis of epigenetic and structural changes of epithelial tumors genome with NotI-microarrays by the example of human chromosome] Pavlova TV, et al. Mol Biol (Mosk), 2009 Mar-Apr. PMID 19425501.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.The ZIC gene family in development and disease. Grinberg I, et al. Clin Genet, 2005 Apr. PMID 15733262.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. Jaster JH. Neurology, 2004 Oct 12. PMID 15477575.
特异性:Human
别名:Zinc finger protein ZIC 4, Zinc finger protein of the cerebellum 4, ZIC4
应用:WB~~1:500~1000
简单描述:mouse Monoclonal ZIC4 Antibody (monoclonal) (M09). Validated for use in WB, IHC, IF, E. Clone: 3A2.