简单描述:Mouse Monoclonal RUNX1 Antibody. Validated for use in WB, ICC, E. Clone: 5A1.
详情:FunctionCBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation.Cellular_LocationNucleus.Tissue_LocationExpressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood