产品概述:This gene encodes the third discovered human homologue ofthe Drosophilia melanogaster type I membrane protein notch. InDrosophilia, notch interaction with its cell-bound ligands (delta,serrate) establishes an intercellular signalling pathway that playsa key role in neural development. Homologues of the notch-ligandshave also been identified in human, but precise interactionsbetween these ligands and the human notch homologues remains to bedetermined. Mutations in NOTCH3 have been identified as theunderlying cause of cerebral autosomal dominant arteriopathy withsubcortical infarcts and leukoencephalopathy (CADASIL). [providedby RefSeq].
靶点/蛋白:This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
来源:Mouse
存储溶液:Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
参考文献:Liu, H., et al. Circ. Res. 107(7):860-870(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Menon, S., et al. Cephalalgia (2010) In press :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
特异性:Human
别名:Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3
应用:WB~~1:100~1600
简单描述:Mouse Monoclonal NOTCH3 Antibody (C-term Q2306) (Ascites). Validated for use in WB, E. Clone: 487CT6.9.2.
详情:FunctionFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).Cellular_LocationCell membrane; Single-pass type I membrane proteinTissue_LocationUbiquitously expressed in fetal and adult tissues