产品概述:Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
靶点/蛋白:Human MEF2A
来源:Mouse
参考文献:Pollock R.,et al.Genes Dev. 5:2327-2341(1991).Treisman R.,et al.Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.Yu Y.-T.,et al.Genes Dev. 6:1783-1798(1992).Suzuki E.,et al.Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.Ota T.,et al.Nat. Genet. 36:40-45(2004).
简单描述:Mouse Monoclonal MEF2A / MEF2 Antibody (clone 1D11). Validated for use in WB, IHC-P, E. Clone: 1D11.
详情:FunctionTranscriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.Cellular_LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}Tissue_LocationIsoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined