产品概述:The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3).
靶点/蛋白:A synthetic peptide corresponding to residues on human Dynamin-1 was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated Dynamin-1.
来源:Rabbit
存储溶液:50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献:1. Sontag JM, et al. J Biol Chem 269(6):4547-54, 1994.
2. Sweitzer SM, et al. Cell 93(6):1021-9, 1998.
3. Marks B, et al. Nature 410(6825):231-5, 2001.
特异性:Human
别名:Dynamin-1, DNM1, DNM
应用:WB~~1:1000~10000
简单描述:Rabbit Monoclonal Dynamin-1 Antibody. Validated for use in WB, IF. Clone: EP772Y.
详情:FunctionMicrotubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.Cellular_LocationCytoplasm. Cytoplasm, cytoskeleton Note=Microtubule-associated