产品概述:This gene encodes a protein with multiple coiled coilmotifs which is located in the nucleus, cytoplasm and mitochondria.The protein is involved in neurite outgrowth and corticaldevelopment through its interaction with other proteins. This geneis disrupted in a t(1;11)(q42.1;q14.3) translocation whichsegregates with schizophrenia and related psychiatric disorders ina large Scottish family. Alternate transcriptional splice variants,encoding different isoforms, have been characterized. [provided byRefSeq].
靶点/蛋白:This DISC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from the C-terminal region of human DISC1.
来源:Mouse
存储溶液:Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
参考文献:Park, Y.U., et al. Proc. Natl. Acad. Sci. U.S.A. 107(41):17785-17790(2010)Raznahan, A., et al. Mol. Psychiatry (2010) In press :Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Kaibuchi, K., et al. Nihon Shinkei Seishin Yakurigaku Zasshi 30(3):149-152(2010)Shulman, J.M., et al. PLoS ONE 5 (6), E11244 (2010) :
特异性:Human
别名:Disrupted in schizophrenia 1 protein, DISC1, KIAA0457
应用:WB~~1:100~8000
简单描述:Mouse Monoclonal DISC1 Antibody (C-term) (Ascites). Validated for use in WB, E. Clone: 584CT4.2.1.
详情:FunctionInvolved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.Cellular_LocationCytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity) Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosomeTissue_LocationUbiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter