产品概述:CD90 (Cluster of Differentiation 90, Thy-1) is a heavily N-glycosylated GPI linked cell surface protein member of the immunoglobulin (Ig) superfamily. As a smallest member of family, CD90 may play a role in cell-to-cell and cell-to-lignand interactions during synaptogensis and other neuron related activities (e.g. neurite outgrowth, nerve regeneration) (1). In developing nervous tissue, CD90 is involved in axon growth regulation by halting axon growth in mature axon via its interaction with intergin-beta-3 on mature astrocytes. Additionally, CD90 has been linked to apoptosis, adhesion, migration, cancer (including cancer stem cells), and fibrosis (2). As a major marker for hematopoietic stem cells (HSCs), CD90 mediates differentiation of HSCs. In stem cancer cell research, CD90+ cells in the hepatocellular carcinoma (HCC) have been shown to display tumorgenic capacity (3).
靶点/蛋白:A synthetic peptide corresponding to residues near the N-terminal of human CD90 was used as an immunogen.
来源:Rabbit
存储溶液:50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献:1. The UniProt Consortium, The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008) 2. TA Rege, JS Hagood., The FASEB Journal 20:1045-1054, 2006 3. ZF Yang et al., Cancer Cell 3(2):153-66, 2008.
简单描述:Rabbit Monoclonal CD90 Antibody. Validated for use in WB, IHC. Clone: EPR3132.
详情:FunctionMay play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.Cellular_LocationCell membrane; Lipid-anchor, GPI-anchor