产品概述:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
靶点/蛋白:Human CaMKK
来源:Mouse
参考文献:Harvey M.,et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.Wiemann S.,et al.Genome Res. 11:422-435(2001).Ishikawa Y.,et al.FEBS Lett. 550:57-63(2003).Daub H.,et al.Mol. Cell 31:438-448(2008).Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
特异性:Human
别名:Calcium/calmodulin-dependent protein kinase kinase 1, CaM-KK 1, CaM-kinase kinase 1, CaMKK 1, 2.7.11.17, CaM-kinase IV kinase, Calcium/calmodulin-dependent protein kinase kinase alpha, CaM-KK alpha, CaM-kinase kinase alpha, CaMKK alpha, CAMKK1, CAMKKA
应用:IHC-P (5 μg/ml), WB (1:500-1:1000),
简单描述:Mouse Monoclonal CAMKK1 Antibody (clone 1F6). Validated for use in WB, IHC-P, E. Clone: 1F6.
详情:FunctionCalcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.Cellular_LocationCytoplasm. Nucleus