产品概述:Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
别名:SH3 domain-binding protein 5, SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SH3BP5, SAB
应用:IF (10 μg/ml), IHC-P (5 μg/ml),
简单描述:Mouse Monoclonal SH3BP5 / SAB Antibody (clone 2B3). Validated for use in WB, IHC-P, IF, E. Clone: 2B3.
详情:FunctionInhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.Cellular_LocationMitochondrion.Tissue_LocationHighly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.