产品概述:Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
来源:Mouse
参考文献:Valenzuela S.M.,et al.J. Biol. Chem. 272:12575-12582(1997).Noh Y.H.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.Chuang J.Z.,et al.J. Neurosci. 19:2919-2928(1999).Ribas G.,et al.J. Immunol. 163:278-287(1999).Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
特异性:Human
别名:Chloride intracellular channel protein 1, Chloride channel ABP, Nuclear chloride ion channel 27, NCC27, Regulatory nuclear chloride ion channel protein, hRNCC, CLIC1, G6, NCC27
应用:IHC-P (2.5 μg/ml)
简单描述:Mouse Monoclonal CLIC1 / NCC27 Antibody (clone 2D4). Validated for use in WB, IHC-P, E. Clone: 2D4.
详情:FunctionCan insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.Cellular_LocationNucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domainTissue_LocationExpression is prominent in heart, placenta, liver, kidney and pancreas.