产品概述:The protein encoded by this gene belongs to the family ofP-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane proteinresponsible for establishing and maintaining the electrochemicalgradients of Na and K ions across the plasma membrane. Thesegradients are essential for osmoregulation, for sodium-coupledtransport of a variety of organic and inorganic molecules, and forelectrical excitability of nerve and muscle. This enzyme iscomposed of two subunits, a large catalytic subunit (alpha) and asmaller glycoprotein subunit (beta). The catalytic subunit ofNa+/K+ -ATPase is encoded by multiple genes. This gene encodes analpha 1 subunit. Multiple transcript variants encoding differentisoforms have been found for this gene.
靶点/蛋白:This ATP1A1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from human ATP1A1.
来源:Mouse
存储溶液:Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
参考文献:Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Holthouser, K.A., et al. Am. J. Physiol. Renal Physiol. 299 (1), F77-F90 (2010) :Comellas, A.P., et al. J. Cell. Sci. 123 (PT 8), 1343-1351 (2010) :Floyd, R.V., et al. Reprod Sci 17(4):366-376(2010)Xu, Z.W., et al. Zhonghua Yi Xue Za Zhi 90(12):813-817(2010)
简单描述:Mouse Monoclonal ATP1A1 Antibody(Ascites). Validated for use in WB, E. Clone: 369CT16.5.2.
详情:FunctionThis is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.Cellular_LocationCell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV