靶点/蛋白:Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 recognizes activated human RAF proto-oncogene serine/threonine-protein kinase, also known as Raf-1 or c-RAF, binding to the phosphorylated serine residue at position 338.Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 binds to Raf-1 that has been activated by Ras or Src, but not to unactivated Raf-1. Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 does not bind to Raf peptides phosphorylated at other sites, including Y341 and S339.Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 has been described for the detection of Ser338 phosphorylated RAF-1 by western blotting (Masonet al.1999).
来源:Rat
参考文献:1. Mason, C.S. et al. (1999) Serine and tyrosine phosphorylations co-operate in Raf-1, but not B-Raf activation EMBO. J. 18: 2137-2148 2. Chiloeches, A. et al. (2001) S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.Mol Cell Biol. 21: 2423-34.