Thymidylate Synthase (5-FU Resistance Marker) Antibody - With BSA and Azide
供应商:
安诺伦(北京)生物科技有限公司
规格:
20 μg
商品分类:单克隆抗体
产品概述:It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
靶点/蛋白:Recombinant human thymidylate synthase
来源:Mouse
存储溶液:0.5 ml at 200ug/ml with BSA and azide
参考文献:1. Johnston PG, et. al. Cancer Research, 1991, 51(24):6668-76.2. Johnston PG, et. al. Cancer Research, 1992, 52(16):4306-12.3. Johnston PG, et. al. Biochemical Pharmacology, 1993, 45(12):2483-6.4. Johnston PG, et. al. Journal of Clinical Oncology, 1994, 12(12):2640-7.5. Johnston PG, et. al. Cancer Research, 1995, 55(7):1407-12.6. Johnston PG, et. al. Journal of the National Cancer Institute, 1997, 89(4):308-13.7. Pestalozzi BC, et. al. Journal of Clinical Oncology, 1997, 15(5):1923-31.
特异性:Human
别名:Thymidylate synthase, TS, TSase, TYMS, TS
简单描述:Mouse Monoclonal Thymidylate Synthase (5-FU Resistance Marker) Antibody - With BSA and Azide. Validated for use in WB, IHC, IF, FC, IP. Clone: TS106 + TMS715.
详情:FunctionContributes to the de novo mitochondrial thymidylate biosynthesis pathway.Cellular_LocationNucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane