产品概述:This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene.
靶点/蛋白:SUGT1 (NP_006695, 151 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
来源:mouse
存储溶液:Clear, colorless solution in phosphate buffered saline, pH 7.2.
参考文献:Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. Davies AE, et al. J Cell Biol, 2010 Apr 19. PMID 20404110.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361. Bansal PK, et al. J Biol Chem, 2009 Jul 10. PMID 19398558.Sgt1 has co-chaperone properties and is up-regulated by heat shock. Zabka M, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18358234.Hsp70 is a new target of Sgt1--an interaction modulated by S100A6. Spiechowicz M, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17466273.
特异性:Human
别名:Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1, SUGT1
应用:WB~~1:500~1000
简单描述:mouse Monoclonal SUGT1 Antibody (monoclonal) (M03). Validated for use in WB, IF, E. Clone: 6G5.