产品概述:The protein encoded by this gene is a plasma proteaseinhibitor and a member of the serpin superfamily. This proteininhibits thrombin as well as other activated serine proteases ofthe coagulation system, and it regulates the blood coagulationcascade. The protein includes two functional domains: the heparinbinding-domain at the N-terminus of the mature protein, and thereactive site domain at the C-terminus. The inhibitory activity isenhanced by the presence of heparin. More than 120 mutations havebeen identified for this gene, many of which are known to causeantithrombin-III deficiency.
靶点/蛋白:This SERPINC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from human SERPINC1.
来源:Mouse
存储溶液:Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
参考文献:Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zhang, G.S., et al. Blood Coagul. Fibrinolysis 21(6):588-591(2010)Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)Picard, V., et al. Biochemistry 34(26):8433-8440(1995)
简单描述:Mouse Monoclonal SERPINC1 Antibody (Ascites). Validated for use in WB, E. Clone: 435CT4.7.4.
详情:FunctionMost important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.Cellular_LocationSecreted, extracellular space.Tissue_LocationFound in plasma.