产品概述:This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
靶点/蛋白:Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).
来源:Mouse
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
参考文献:Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis. HarslTf T, et al. Calcif Tissue Int, 2010 Jul. PMID 20508921.DNA methylation of the RIZ1 tumor suppressor gene plays an important role in the tumorigenesis of cervical cancer. Cheng HY, et al. Eur J Med Res, 2010 Jan 29. PMID 20159667.Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. de Vogel S, et al. Cancer Epidemiol Biomarkers Prev, 2009 Nov. PMID 19843671.Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2. Rossi V, et al. J Cell Physiol, 2009 Dec. PMID 19746436.RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression. Lakshmikuttyamma A, et al. J Hematol Oncol, 2009 Jul 14. PMID 19602237.
特异性:Human, Mouse
别名:PR domain zinc finger protein 2, GATA-3-binding protein G3B, Lysine N-methyltransferase 8, MTB-ZF, MTE-binding protein, PR domain-containing protein 2, Retinoblastoma protein-interacting zinc finger protein, Zinc finger protein RIZ, PRDM2, KMT8, RIZ
应用:WB~~1:1000CHIP~~1:100
简单描述:Mouse Monoclonal PRDM2 (RIZ1) Antibody. Validated for use in IP, CHIP, WB, E. Clone: 33AT1045.
详情:FunctionS-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.Cellular_LocationNucleusTissue_LocationHighly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen Isoform 1 is expressed in testis at much higher level than isoform 3.