产品概述:Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
靶点/蛋白:Recognizes the ovarian cancer mucin CA125 (also known as MUC16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number ...
别名:MUC16, CA125 ovarian cancer antigen, CA125, CA-125, MUC-16, Mucin-16
应用:IHC-P (10 μg/ml),
简单描述:Mouse Monoclonal MUC16 / CA125 Antibody (Extracellular Domain, clone X325). Validated for use in WB, IHC-P, E. Clone: X325.
详情:FunctionThought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.Cellular_LocationCell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domainTissue_LocationExpressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas