产品概述:Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.
靶点/蛋白:Purified His-tagged Mouse Irgm1 protein was used to produced this monoclonal antibody.
来源:Mouse
存储溶液:Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
参考文献:Dhar, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(27):12275-12280(2010)Xu, H., et al. FASEB J. 24(5):1583-1592(2010)Henry, S.C., et al. J. Leukoc. Biol. 87(2):333-343(2010)Zhao, Y.O., et al. PLoS ONE 5 (1), E8648 (2010) :Tiwari, S., et al. Nat. Immunol. 10(8):907-917(2009)
特异性:Mouse
别名:Immunity-related GTPase family M protein 1, 365-, Interferon-inducible GTPase 3, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47, LRG-47, Irgm1, Ifi1, Iigp3, Irgm
应用:WB~~1:100~500
简单描述:Mouse Monoclonal Mouse Irgm1 Antibody (C-term). Validated for use in WB, E. Clone: 403CT8.5.5.
详情:FunctionPutative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.Cellular_LocationGolgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Late endosome membrane Cell projection, phagocytic cup. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Preferentially associated with cis- and medial-Golgi. Also detected in late endosomes and lysosomesTissue_LocationExpressed in lung and primary macrophages.