产品概述:CD20, also known as B1 and MS4A1, is a human B lymphocyte surface molecule expressed on both normal and malignant cells that functions as a receptor during B cell activation. It is also involved in the regulation of cell progression in B lymphocyrtes as either a component or a regulator of intracellular calcium levels (1-2). CD20 is phosphorylated on serines primarily and threonines but not tyrosines. Monoclonal antibodies against CD20 are used to treat B-cell non-Hodgkins lymphoma (3).
靶点/蛋白:A synthetic peptide corresponding to residues in the C-term of human CD20 was used as immunogen.
来源:Rabbit
存储溶液:50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献:1. Tedder, T. F.; Klejman, G.; Schlossman, S. F.; Saito, H.: J. Immun. 142: 2560-2568, 1989.
2. Tedder, T. F.; Streuli, M.; Schlossman, S. F.; Saito, H.:Proc. Nat. Acad. Sci. 85: 208-212, 1988.
3. Fischer M, Behr T, Grunwald F, Knapp WH, Trumper L, von Schilling C; German Society for Hematology and Oncology, Nuklearmedizin. 2004 Oct;43(5):171-6.
简单描述:Rabbit Monoclonal CD20 Antibody (C-term). Validated for use in WB, IHC. Clone: EP459Y.
详情:FunctionThis protein may be involved in the regulation of B-cell activation and proliferation.Cellular_LocationCell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchorTissue_LocationExpressed on B-cells.