产品概述:Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
靶点/蛋白:Targets P16. Shows reactivity with Human, Mouse, and Rat samples.
简单描述:Mouse Monoclonal CDKN2A / p16INK4a Antibody (clone 1E12E10). Validated for use in WB, IHC-P, E. Clone: 1E12E10.
详情:FunctionActs as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.Cellular_LocationCytoplasm. NucleusTissue_LocationWidely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific