靶点/蛋白:Smooth plasma membrane fraction of MeWo cells
来源:Mouse
存储溶液:0.5ml at 100ug/ml with BSA and azide
参考文献:1.? C. Vennegoor et al., Int. J. Cancer 35: 287-295, 1985. 2.?AA Palmer et al., Pathology 17: 335-339, 1985. 3. EC Hagen et al., Histopathology 10: 689-700, 1986.
简单描述:Mouse Monoclonal CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone NKI/C3]. Validated for use in IF, FC. Clone: NKI/C3.
详情:FunctionFunctions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.Cellular_LocationCell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodiesTissue_LocationDetected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages