Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - Without BSA and Azide
供应商:
安诺伦(北京)生物科技有限公司
规格:
100 μg
商品分类:单克隆抗体
产品概述:PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APā€?s in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This MAb binds equally well to all common allelic variants (S, F, FS and I) of PLAP as to AP from normal human testis. This MAb can be used both as coating as well as tracer antibody in the same ELISA to detect PLAP in serum of S, F, FS and I phenotypes.
来源:Mouse
参考文献:Millan J.L. et. al., Antigenic determinants of human placental and testicular alkaline phosphatase as mapped by monoclonal antibodies. Eur. J. Biochem. 136: 1-12, (1983). | Riklund K.E. et. al., Experimental radio-immunotherapy of HeLa tumors in nude mice with 131I-labeled monoclonal antibodies. Anticancer Research, 1990, 10:379-84
简单描述:Mouse Monoclonal Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - Without BSA and Azide. Validated for use in IHC-F, IF, FC. Clone: ALPP/238.
详情:Cellular_LocationCell membrane; Lipid-anchor, GPI-anchor.Tissue_LocationDetected in placenta (at protein level).