产品概述:Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
靶点/蛋白:This AIM2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-32 amino acids from human AIM2.
来源:Mouse
存储溶液:Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
参考文献:DeYoung K.L., et al. Oncogene 15:453-457(1997).Ota T., et al. Nat. Genet. 36:40-45(2004).Gregory S.G., et al. Nature 441:315-321(2006).Cresswell K.S., et al. Biochem. Biophys. Res. Commun. 326:417-424(2005).Chen I.-F., et al. Mol. Cancer Ther. 5:1-7(2006).
特异性:Human
别名:Interferon-inducible protein AIM2, Absent in melanoma 2, AIM2
应用:WB~~1:2000
简单描述:Mouse Monoclonal AIM2 Antibody(Ascites). Validated for use in WB, E. Clone: 812CT9.2.2.1.
详情:FunctionInvolved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.Cellular_LocationNucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particlesTissue_LocationExpressed in spleen, small intestine, peripheral blood leukocytes, and testis