产品概述:The T cell coreceptor CD8 is a cell-surface glycoprotein expressed either as a disulfide-linked homodimer of two CD8alpha monomers, or a heterodimer of CD8alpha and CD8beta. These receptors interact with ligands, such as major histocompatibility complex (MHC) class I, on the outside of the cell, with proteins inside the cell, such as the tyrosine kinase p56lck, and possibly with proteins on the same cell-surface (1). CD8 plays an important role in T cell development in the thymus and T cell activation in the periphery (2).
靶点/蛋白:A synthetic peptide corresponding to residues near the C-terminus of human CD8 alpha chain was used as an immunogen.
来源:Rabbit
存储溶液:50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献:1. Devine L, et al. Immunol Res, 19(2-3):201-10, 1999.2. Wong, JS, et al. J Immunol 171:867-874, 2003
简单描述:Rabbit Monoclonal CD8 Antibody (C-term). Validated for use in WB, IHC. Clone: EP1150Y.
详情:FunctionIdentifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.Cellular_LocationIsoform 1: Cell membrane; Single-pass type I membrane protein