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- 保存条件:
冷藏
- 保质期:
长期
- 英文名:
Recombinant Human Programmed Cell Death 1 Ligand 1
- 库存:
244
- 供应商:
北京百奥莱博科技有限公司
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博专业生产销*(代"售")JN1525型重组人B7-H1(PD-L1)厂家,我公司供应的分子生物学试剂品类齐全,且具有优势价格,欢迎新老客户垂询订购。
名称:JN1525型重组人B7-H1(PD-L1)厂家
品牌:百奥莱博
编号:JN1525
英文名:Recombinant Human Programmed Cell Death 1 Ligand 1
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Phe19-Thr239在C端带有Fc标签。
B7-H1/PD-L1质量控制:>95%(还原性SDS-PAGE)
B7-H1/PD-L1制剂:冻干品
B7-H1/PD-L1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
B7-H1/PD-L1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于B7-H1/PD-L1:
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
除JN1525型重组人B7-H1(PD-L1)厂家外,我公司正在打折促销以下产品:
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ARB13770 家蚕卵黄蛋白(LT)elisa检测 Bombyx mori livetin,lt ELISA KIT
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N-*甲酰-L-酪*酰乙酯 D-Panthenol 3483-82-7
BL1224 GoldViewⅡ型核酸染色剂(5000×)
BL1396 SABC小鼠/兔IgG-AP kit
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JN1525型重组人B7-H1(PD-L1)厂家关键词:重组人B7-H1蛋白,JN1525,重组B7-H1,重组人PD-L1
·重组小鼠IL-22(C端带mFc标签)
编号:JN1519
英文名称:Recombinant Mouse Interleukin-22
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Leu34-Val179在C端带mFc标签。
IL-22质量控制:>95%(还原性SDS-PAGE)
IL-22制剂:冻干品
IL-22保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
IL-22复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于IL-22:
Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79% and 22% sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.
JN1525型重组人B7-H1(PD-L1)厂家关键词:重组人B7-H1蛋白,JN1525,重组B7-H1,重组人PD-L1
·重组人EphB1
编号:JN1132
英文名称:Recombinant Human Ephrin Type-B Receptor 1
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Met18-Pro540在C端带有Fc标签。
EPHB1质量控制:>95%(还原性SDS-PAGE)
EPHB1制剂:冻干品
EPHB1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
EPHB1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于EPHB1:
Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases involved in the development of embryonic nervous and vascular systems. EPHB1 contains two fibronectin type-III domains, one protein kinase domain and one Sterile Alpha Motif (SAM)domain. EPHB1 is able to stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which is also correlated with its association with Grb7, an adaptor molecule implicated in the regulation of cell migration. It binds to Ephrin-B1, Ephrin-B2 and Ephrin-B3. EPHB1 plays an important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapsis formation and maturation and may be involved in cell-cell interactions in the nervous system.
北京百莱博科技有限公司专业生产分子生物学试剂产品,欢迎来电咨询选购JN1525型重组人B7-H1(PD-L1)厂家。
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文献和实验,PD-1/PD-L1这么值钱,大家一定好奇它到底是什么鬼。 PD-1全名是程序性死亡分子1(programmed death-1)是Ishida等[1]通过消减杂交技术于1992年发现的[2],是CD28家族成员,胞质区含有2个酪氨酸残基,1个位于靠近N端的免疫受体酪氨酸抑制基序(ITIM)中,另一个1个位于靠近C端的免疫受体酪氨酸转化基序(ITSM)中[2]。 PD-L1(CD274)是B7家族成员,是PD-1的配体,属于1型跨膜蛋白,全长290个氨基酸,包含1个IgV样
28、CTLA-4的局限性表达(主要在T细胞)不同,PD-1可表达于活化的T细胞、B细胞和骨髓细胞,以及CD4-CD8-胸腺细胞[1]。PD-1有两个配体,PD-L1(B7-H1)和PD-L2(B7-DC),均为B7家族中的新成员,胞外都有1个IgV样区和1个IgC样区。PD-L1含有290个氨基酸,其胞外区与B7-1、B7-2分别有20%和15%的同源性,胞浆区变化多样,但二级结构同B7-1、B7-2非常相似。在基因水平上PD-L2与PD-L1有37.4%的同源性。PD-L1和PD-L2的表达与调节不同
(无)条带,如抗体无专一性则条带无变化举个例子,癌症免疫常用的 PD-L1 抗体,下图可看到 GTX104763 PD-L1 抗体,使用基因敲弱的细胞裂解液,WB 的条带会随之变弱,显示 GTX104763 抗体具有高特异性。GTX104763 还适合多种应用,包括 WB、ICC/IF、IHC-P(可达 1:1,000)、 IHC-Fr(可达 1:1,000),及多篇文献引用,为高敏、高特异性的可靠抗体工具。又如白血病标记物-CD44,CD44 参与介导细胞存活的迁移、增殖、分化和信号传导途径。GTX
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