北京重组小鼠TREM-2b(髓细胞触发受体2b)(C端带Hi

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专业生产销*(代"售")北京重组小鼠TREM-2b(髓细胞触发受体2b)(C端带His标签)品牌，我公司供应的分子生物学试剂品类齐全，且具有优势价格，欢迎新老客户垂询订购。

名称：北京重组小鼠TREM-2b(髓细胞触发受体2b)(C端带His标签)品牌
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Mouse Triggering Receptor Expressed on Myeloid Cells 2b
品牌：百奥莱博
编号：JN1535
产地：国产|进口
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu19-Pro168在C端含有His标签。

TREM-2b 质量控制：＞95%(还原性SDS-PAGE)

TREM-2b 制剂：冻干品

TREM-2b 保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TREM-2b 复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TREM-2b ：
Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages, osteoclasts, microglia and dendritic cells. TREM-2 is one member of the TREM family, inhibiting the releasing of inflammatory mediators, so it is an important in vivo anti-inflammatory receptor. TREM-2 consists of an 18 aa signal sequence, a 153 aa extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161. TREM-2 transduces intracellular signals through the adaptor DAP12. After binding of TREM-2 with ligand, the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions, which then activate the myeloid cells and participate T cell responses.

更多有关北京重组小鼠TREM-2b(髓细胞触发受体2b)(C端带His标签)品牌的价格及使用说明等，请联系我们的业务经理王欣女士咨询，我公司还销*(代"售")以下产品：

·重组小鼠趋化因子CCL2(MCP-1)(带His标签)
编号：JN0332
英文名称：Recombinant Mouse C-C motif chemokine 2
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Gln24-Asn148在C端含有His标签。

CCL2/MCP-1质量控制：＞95%(还原性SDS-PAGE)。

CCL2/MCP-1制剂：液体

CCL2/MCP-1保存：
收到后请置于-20℃，可稳定保存6个月，避免反复冻融。

关于CCL2/MCP-1：
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.


北京重组小鼠TREM-2b(髓细胞触发受体2b)(C端带His标签)品牌关键词：JN1535,重组小鼠TREM-2b蛋白,重组小鼠髓细胞触发受体2b,C端带His标签

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北京重组小鼠TREM-2b(髓细胞触发受体2b)(C端带His标签)品牌关键词：JN1535,重组小鼠TREM-2b蛋白,重组小鼠髓细胞触发受体2b,C端带His标签

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