重组人Serpin B9(丝氨酸蛋白酶抑制剂B9) 分子生物

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专注于生命科学和生物技术领域，致力于为客户提供包括重组人Serpin B9(丝*酸蛋白酶抑制剂B9) 分子生物学试剂在内的一系列分子生物学试剂产品，并提供一系列相关的技术服务。

名称：重组人Serpin B9(丝*酸蛋白酶抑制剂B9)
英文名：Recombinant Human Serine Protease Inhibitor-clade B9
规格：10μg|50μg|500μg|1mg
编号：JN1303
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Met1-Pro376在C端含有His标签。

Serpin B9质量控制：＞95%(还原性SDS-PAGE)

Serpin B9制剂：冻干品

Serpin B9保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Serpin B9复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Serpin B9：
Serpin B9, also known as Cytoplasmic antiproteinase 3(CAP-3), is a cytoplasm protein which belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases.Serpin B9 is an inhibitor of the granzyme B/perforin lytic pathway. It is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis. Serpin-B9 expression in immune-privileged cells, APCs, and CTLs protects these cells against the actions of granzyme B, and when expressed in tumor cells or virally infected hepatocytes, confers resistance to killing by CTL and NK cells. Expression of increasing levels of Serpin-B9 in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin / granzyme pathway and then through the Fas / FasL pathway.
关键词：重组人Serpin B9蛋白,JN1303,重组人丝*酸蛋白酶抑制剂B9,重组Serpin B9


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