- $50 - 250
- PROSPEC
- 以色列
- CYT-874
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
见说明书
- 保质期：
12个月
- 英文名：
Apolipoprotein E3 Human Recombinant
- 库存：
60
- 供应商：
上海信裕生物科技有限公司
- 规格：
5µg 20µg 1mg
CATALOGUE NUMBER
CYT-874
SYNONYMS
Apolipoprotein E, LDLCQ5, APO-E, LPG, AD2, Alzheimer Disease 2 (APOE*E4-Associated, Late Onset), Apolipoprotein E3, APOE.INTRODUCTION
Apolipoprotein E3 (ApoE) is a 34kDa protein component of serum chylomicrons, VLDL, and HDL particles. ApoE mediates the binding, uptake, and catabolism of these particles as a result of interactions with the ApoE receptor and LDL receptors in the liver and brain. ApoE is imperative in fatty acid homeostasis and memory formation. Polymorphisms encode 3 variants (ApoE2, 3, 4), which are differentially connected to the development of atherosclerosis and neurogenerative disorders, mainly Alzheimer's disease.DESCRIPTION
APOE3 Human Recombinant (19-317) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 306 amino acids and having a molecular mass of 35kDa.The APOE is fused to a 7 amino acid His tag [M-HHHHHH] at N-terminus and purified by proprietary chromatographic techniques.
SOURCE
Escherichia Coli.PHYSICAL APPEARANCE
Sterile Filtered White lyophilized (freeze-dried) powder.FORMULATION
Lyophilized from a 0.2µm filtered solution in PBS.SOLUBILITY
It is recommended to reconstitute the lyophilized APOE in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.STABILITY
Lyophilized APOE3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APOE should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
PURITY
Greater than 95% as determined by SDS-PAGE.AMINO ACID SEQUENCE
MHHHHHHKVE QAVETEPEPE LRQQTEWQSG QRWELALGRF WDYLRWVQTL SEQVQEELLS SQVTQELRAL MDETMKELKA YKSELEEQLT PVAEETRARL SKELQAAQAR LGADMEDVCG RLVQYRGEVQ AMLGQSTEEL RVRLASHLRK LRKRLLRDAD DLQKRLAVYQ AGAREGAERG LSAIRERLGP LVEQGRVRAA TVGSLAGQPL QERAQAWGER LRARMEEMGS RTRDRLDEVK EQVAEVRAKL EEQAQQIRLQ AEAFQARLKS WFEPLVEDMQ RQWAGLVEKV QAAVGTSAAP VPSDNH.BIOLOGICAL ACTIVITY
Immobilized rHuApoE3 binds to rMuVLDLR with EC50 less than 0.4µg/ml.USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验施一公团队 2023 首秀！发现 APOE4 受体，揭示阿尔兹海默症潜在致病因子
导读 APOE 的基因产物 APOE 在脂质代谢、免疫调节和神经学中起着关键作用。最常见的三种 APOE 等位基因对应于三种蛋白质异构体，分别是 APOE2、APOE3 和 APOE4，它们仅在 112 和 158 两个氨基酸位置上存在差异。尽管只存在微小差别，但前期的研究数据表明，这些 APOE 亚型在生理和病理学层面却表现出不同的作用。 其中，APOE 的免疫调节作用最初是作为血浆脂蛋白对 T 细胞增殖抑制作用的一部分被发现的。研究表明，APOE 能够抑制 T 细胞增殖和中
APOE-Based Models of Pre-Dementia
Producing a valid animal model of apolipoprotein E (APOE )-based dementia is critical to understanding the etiology and progression of late-onset Alzheimer’s disease (AD). Unfortunately, no such model exists. Herein, I review
Laser-Capture Microdissection of Hyperlipidemic/ApoE/ Mouse Aorta Atherosclerosis
roles have not been defined. To map these infiltrates, we employed laser-capture microdissection (LCM) to isolate the three arterial wall laminae using apoE−/− mouse aorta as a model. RNA from LCM-separated tissues was extracted and large-scale
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