All You Need for Angiotensin II Receptor Research
Cat #: ESD-950
16 Vials
Alomone Labs is pleased to offer the Angiotensin II Receptor Deluxe Research Pack (#ESD-950). The Research Pack contains all you need for angiotensin II receptor research, all in one economical package!
Compounds
Scientific Background
Related Products
Product Name
Cat #
Size
Anti-Angiotensin II Receptor Type-1 (extracellular)
AAR-011
1 x 0.2 ml
Anti-Angiotensin II Receptor Type-1 (extracellular)-ATTO-550
AAR-011-AO
1 x 50 µl
Anti-Angiotensin II Receptor Type-2 (extracellular)
AAR-012
1 x 0.2 ml
Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO-488
AAR-012-AG
1 x 50 µl
Angiotensin A (1-8)
SPA-105
1 x 10 mg
Angiotensin II acetate
SPA-165
1 x 50 mg
[D-Ala7]-Angiotensin I/II (1-7)
SPA-160
1 x 10 mg
Azilsartan
A-245
1 x 25 mg
Candesartan cilexetil
C-265
1 x 1 g
Novokinin
SPA-125
1 x 5 mg
PD 123319 ditrifluoroacetate
P-245
1 x 10 mg
Telmisartan
T-170
1 x 1 g
Scientific Background
Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.
Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
References
Mukoyama, M. et al. (1993) J. Biol. Chem. 268, 24539.
De Gasparo, M. et al. (2000) Pharmacol. Rev.52, 415.
Carey, R.M. and Siragy, H.M. (2003) Endocr. Rev. 24, 261.