A Screening Package of KCa2 Channel Modulators Economically Priced
Cat #: EK-122
9 Vials
KCa2 channels are extremely sensitive to the levels of intracellular Ca2+ and concentrations as low as 300-700 nM can open the channels very rapidly (5-15 ms). Hence, the KCa2 channels are highly sensitive and fast Ca2+ sensors resembling other known Ca2+-binding proteins. This type of Ca2+-dependent activation is achieved by the constitutive binding of the KCa2 channels to calmodulin, a highly expressed Ca2+-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-terminus.
Pharmacologically, the KCa2 channels are the only known targets of the bee venom toxin Apamin, with KCa2.1 being the less sensitive, KCa2.2 the most sensitive and KCa2.3 showing intermediate sensitivity.
Alomone Labs is pleased to offer the KCa2 Channel Modulator Explorer Kit (#EK-122). The Explorer Kit contains KCa2 blockers, and openers ideal for screening purposes.
Compounds
References
Product Name
Cat #
Size
Apamin
STA-200
1 x 0.1 mg
CyPPA
C-110
1 x 5 mg
1-EBIO
E-150
1 x 10 mg
NS-309
N-180
1 x 5 mg
NS-4591
N-325
1 x 5 mg
NS8593 hydrochloride
N-195
1 x 5 mg
Scyllatoxin
STS-370
1 x 50 µg
SKA-31
S-120
1 x 5 mg
Tamapin
STT-400
1 x 0.1 mg
KCa2-Related Channel Modulator Explorer KitReferences