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液体
-20℃冻存,避光
多克隆
人,小鼠,大鼠
二年
YT706
多克隆抗体
849
北京百奥莱博科技有限公司
兔
WB,IHC
1mg/ml
Cyclin D1 Rabbit Polyclonal Antibody
兔抗Cyclin D1多克隆抗体抗体
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博供应的兔抗Cyclin D1抗体 一抗用于科研实验,本产品质量好,且极具价格优势,深为用户称道,了解更多兔抗Cyclin D1抗体等一抗产品请联系我司咨询订购。
名称:兔抗Cyclin D1抗体 一抗
编号:YT706
规格:50μl
英文名:Cyclin D1 Rabbit Polyclonal Antibody
本品为来源于兔的抗细胞周期蛋白D1(Cyclin D1)的多克隆抗体。
宿主:兔
克隆性:多克隆抗体
用途:WB,IHC
交叉反应性:人,小鼠,大鼠
分子量:36KDa
推荐稀释比例:WB(1:1000),IHC(1:100)
About this Antibody | |
Name | Cyclin D1 Rabbit Polyclonal Antibody |
Category | Polyclonal antibody(pAb); Primary antibody |
Isotype | IgG |
Purification | Peptide affinity purified |
About the Immunogen | |
Immunogen | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to N-terminal residues of mouse Cyclin D1. |
Gene ID | 595 |
SwissProt | P24385 |
Synonyms | CCND1;BCL1; D11S287E; PRAD1; U21B31 |
Category | Cell Cycle / Checkpoint Control |
Background | Cyclins function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. Cyclin D1 has been found to be overexpressed in breast carcinoma. Its potential use as a biomarker was suggested . |
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