Anti-SMAD7 Polyclonal Antibody

英文名称Rabbit SMAD7 Polyclonal Antibody别名BIP;GRP78;HEL-S-89n;MIF2应用WB稀释比例WB1:500-1:2000交叉反应Mouse,Rat蛋白分子量46kDaGene ID4092保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原A synthetic peptide of human SMAD7性状Lyophilized or LiquidSwiss ProtO15105克隆类型Polyclonal Antibody来源Rabbit背景资料The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.