英文名称Rabbit TGFB1 Polyclonal Antibody别名CED;DPD1;LAP;TGFB;TGFbeta
应用WB,IHC稀释比例WB1:500-1:2000 IHC1:50-1:200交叉反应Human,Mouse,Rat蛋白分子量44kDaGene ID7040保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原Recombinant protein of human TGFB1性状Lyophilized or LiquidSwiss ProtP01137克隆类型Polyclonal Antibody来源Rabbit背景资料This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.