Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
储存液
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
Recombinant protein of human BMPR2
性状
Lyophilized or Liquid
Swiss Prot
Q13873
克隆类型
Polyclonal Antibody
来源
Rabbit
背景资料
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.