DNA binding protein RFX5, Regulatory factor X 5, RFX5
应用
WB,IHC,IF
稀释比例
WB1:500-1:2000 IHC1:50-1:200 IF1:50-1:100
交叉反应
Human
蛋白分子量
65kDa
Gene ID
5993
保存
Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
储存液
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
Recombinant protein of human RFX5
性状
Lyophilized or Liquid
Swiss Prot
P48382
克隆类型
Polyclonal Antibody
来源
Rabbit
背景资料
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.