产品名:地塞米松 ,98% 英文名: Dexamethasone CAS号:50-02-2 分子式:C22H29FO5 分子量:392.46 Beilstein号:2066651 EC号:200-003-9 MDL号:MFCD00064136 PubChem编号:24893536 属性 溶解性Soluble in ethanol (25 mg/ml), and DMSO (25 mg/ml). Insoluble in water. 敏感性对光线和空气敏感 存贮条件否 熔点262-264°C 密度否 荧光否 IC50否 pK Values否 描述 别名21α-乙酰氧基-9α-氟-11β;17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮;9α-氟-16α-甲基氢化泼尼松;9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮;德沙美松;氟美松;(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F 用途An antiinflammatory glucocorticoid 生化机理Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. Dexamethasone is an activator of IDO.